Today, we bring you another of our popular ingredients which has shown significant results in improving the overall well-being of patients. It’s called Alpha-Ketoglutarate (AKG) and it emerges as a potent ingredient that has a lot of unique benefits. At Personalized Nutrients, we are dedicated to harnessing the complete potential of this ingredient by delving deeper into the science behind AKG. We will help you develop custom supplement formulas using this ingredient in line with the unique requirements of each patient. This will help you optimize your approach to patient care for better patient outcomes.
The Role of AKG in Health and Wellness
AKG is one of the most critical intermediary metabolites in the Krebs cycle, which is also known as the citric acid cycle or TCA (tricarboxylic acid) cycle. This helps in cellular respiration and helps in the production of ADP (adenosine triphosphate) which is the primary energy unit of the cell. AKG is involved in multiple metabolic pathways and is integral to adequate cellular function and maintaining overall health.
Mitochondrial Function and Energy Production
AKG plays a crucial role in the mitochondrial function. It acts as a substrate and helps in the production of succinyl-CoA which is a precursor molecule in the TCA cycle. AKG helps in optimizing mitochondrial efficiency and supports robust energy production. This eventually maintains cellular integrity, promotes tissue repair, and sustains overall vitality.
Healthy Aging
One of the most significant benefits of AKG is that it promotes healthy aging. AKG is not available in the human diet, so direct supplementation is the only feasible way to uptake it. Interestingly, human plasma AKG levels declined approximately 10-fold between the ages of 40 and 80. Custom AKG supplements can mitigate this decline and preserve mitochondrial health. This enhances resilience against age-related stressors and promotes healthy aging. Also, AKG has a lot of anti-oxidant properties and helps combat oxidative damage which is a major cause of cellular degeneration.
Regulation of Blood Glucose and Better Metabolism
AKG’s contribution to Blood glucose regulation and improving metabolism is significant. It modulates glucose metabolism by activating metabolic pathways that are involved in glucose utilization and insulin sensitivity. AKG helps in regulating blood sugar levels and reduces the risk of metabolic disorders by promoting the uptake of glucose into the cells and enhancing insulin signaling.
Protein Synthesis and Muscle Health
The role of AKG in protein metabolism is remarkable. It serves as a precursor for the synthesis of glutamate which is an amino acid that is responsible for forming other amino acids and proteins. Therefore, custom AKG formulations can significantly help with tissue repair, muscle growth, recovery from injury, enhanced physical activity, and improved overall health.
Nitric Oxide Production and Cardiovascular Health
NO production is another key significance of this ingredient and when recommended to patients via custom supplements can contribute to better vasodilation, neurotransmission, and immune regulation. AKG activates endothelial nitric oxide synthase (eNOS), which is the enzyme responsible for Nitric Oxide synthesis in blood vessels. This results in better cardiovascular health in individuals who are impacted by hypertension, atherosclerosis, or endothelial dysfunction through improving the blood flow.
Build Custom AKG Supplements with Personalized Nutrients
Although AKG plays a significant role in improving metabolism and cellular functions, it’s not readily available in significant quantities in the diet. Therefore, custom supplement blends are essential for getting adequate dosages of AKG for better anti-aging-related benefits.
Personalized Nutrients will help you build custom supplement formulations using AKG for individual patient needs using state-of-the-art formulator technology. You define the dosages and ensure that your patients receive all the benefits for optimum health and longevity.
