The NLRP3 inflammasome plays a significant role when it comes to age-related inflammation. It has a complex molecular structure that is the protector of our immune system. But, when it’s activated chronically, it can lead to a plethora of inflammatory responses and cause inflammaging. The process primarily involves releasing pro-inflammatory cytokines such as interleukin-1β and interleukin-18 which eventually leads to pyroptosis. It’s the programmed death of body cells that results in inflammation.
Environmental factors along with modern lifestyle choices usually trigger the NLRP3 activation while on the other hand, genetic factors may amplify or dampen it. This complex mechanism leads to inflammatory responses by the body which vary from individual to individual. As a result, it demands the need for personalized supplementation strategies that help in modulating and controlling inflammaging.
Watch Dr. Bob Miller’s Complete Webinar on Inflammaging
Recently, one of our long-term partners and practitioners Dr. Bob Miller, a traditional naturopath and founder of Functional Genomic Analysis, conducted a webinar on how practitioners can combat age-related inflammaging issues in their patients using custom and highly targeted nutraceutical formulation. He discussed how Personalized and Compounded Nutrients have helped him develop numerous custom formulas that can help patients in overcoming age-related inflammaging that happens due to multiple environmental and genetic factors and boost longevity.
Helping Practitioners Build Custom Inflammaging Nutraceutical Formulas
Dr. Bob Miller has custom formulated three popular nutraceutical supplements in partnership with Compounded Nutrients to help practitioners and their patients combat age related inflammaging.
Those formulas includes –
- XOME
- CALCI CALM
- AUTOPHAGY SUPPORT
These have proven to be significant breakthroughs in managing and regulating age related inflammaging in individuals caused due to environmental and genetic factors.
Practitioners can use these formulas as it is and recommended to their patients in line with their custom supplementation regimens to combat inflammaging. Also, they can use these in-house formulas as a foundation to add their own customizations and build a completely new personalized inflammaging nutraceutical formula.
Let’s have a detailed look at each of them and how they help with longevity.
XOME: Target Numerous Inflammatory Pathways
XOME is our popular in-house custom formula that helps with inflammaging by targeting various inflammatory pathways in the body. It’s made with key ingredients like Riboflavin, California Poppy, Quercetin, Skullcap Root Extract, Pomegranate fruit extract, Magnolia Bark Extract, Boswellia Serrata Extract, Bergamot, Paractin, Hops Extract, L-Theanine, Licorice Root Extract, Luteolin, and Fisetin.
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- Riboflavin is an enhanced bioavailable form of Vitamin B2 that acts as a master antioxidant and helps in reducing oxidative stress in the cells.
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- California poppy is a natural calming agent that helps in lowering neuroinflammation and modulates inflammatory responses and signaling.
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- Quercetin is a powerful flavonoid that directly inhibits NLRP3 inflammasome by acting as an antioxidant and supporting immune system response.
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- Skullcap root extract supports a balanced immune system through compounds that specifically target inflammatory pathways.
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- Pomegranate Fruit Extract has numerous potent antioxidant properties that maintain cellular integrity and support healthy aging.
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- Magnolia Bark Extract Supports healthy stress response and modulates inflammatory signaling pathways to promote cellular resilience.
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- Boswellia Serrata Extract is rich in boswellic acids and specifically targets LOX-5 inflammatory pathways. Promotes tissue health and healthy inflammatory response.
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- Bergamot modulates lipid metabolism and prevents inflammation in the cardiovascular system.
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- Paractin modulates NF-KB proteins to support joint health and maintain healthy inflammatory responses across joints.
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- HOPS Extract helps in modulating oxidative stress and provides numerous benefits to cellular health.
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- L-theanine promotes cell relaxation, cognitive function, and healthy stress response to modulate the inflammatory pathways.
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- Luteolin directly helps in inhibiting the NLRP3 enzyme to support neurological health and modulate inflammatory signaling through multiple anti-oxidant properties.
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- Fisetin supports cellular health and promotes longevity by eliminating senescent cells and combating inflammaging.
CALCI CALM: Mineral Boosted Anti-inflammatory Support Formula
Calci Calm is another inflammatory support formula developed in-house at Personalized Nutrients that practitioners can recommend to their patients and help them combat inflammaging. It’s developed using a unique combination of ingredients which includes Magnesium as Dimagnesium Malate, Zinc, Vitamin K2, Taurine, Witch Hazel Extract, Catalase, Cat’s Claw Bark Extract, Grape Seed Extract, SOD also known as Prickly Pear Cactus, Resveratrol Root Extract, and Rosemary Dry Extract.
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- Magnesium as Dimagnesium Malate is a highly bioavailable form of magnesium that benefits neuromuscular function and supports energy production and regulation to combat inflammaging.
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- Zinc facilitates immune function, cellular repair, and protein synthesis.
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- Vitamin K2 helps in directing calcium to the relevant tissues, supports bone metabolism, and promotes healthy aging.
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- Taurine supports osmoregulation, promotes cellular protection, and also helps in supporting cardiovascular health.
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- Witch Hazel Extract supports vascular health and helps maintain the integrity of the tissues.
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- Catalase acts as an antioxidant enzyme that supports cellular protection and promotes healthy aging.
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- Cat’s Claw Bark Extract supports immune system function and promotes, and regulates healthy inflammatory responses to benefit overall cellular health.
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- Grape Seed Extract has numerous anti-oxidant properties that support vascular health and promote cellular protection.
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- SOD also known as Prickly Pear Cactus promotes cellular anti-oxidation, neutralizes free radicals, and supports healthy aging.
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- Resveratrol Root Extract activates SIRT1 pathways to support healthy mitochondrial function, and cardiovascular health and promote longevity.
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- Rosemary Dry Extract has powerful anti-oxidants that support cognitive function and benefit cellular protection.
AUTOPHAGY SUPPORT: Maximize Cellular Cleanup
Autophagy support is widely preferred by practitioners when it comes to combating inflammaging through custom supplementation. It’s one of our leading in-house formulas developed with a combination of ingredients that consists of Magnesium BHB, Berberine Root Extract, Resveratrol Root Extract, Turmeric Extract, Pterostilbene, and Magnolia Bark Extract.
- Magnesium BHB enhances cellular energy production, promotes autophagy, and streamlines metabolic health.
- Berberine Root Extract activates AMPK pathways to support metabolic health, glucose metabolism, and cellular cleanup.
- Resveratrol Root Extract helps in the activation of Sirtuin pathways to support mitochondrial function, promote cellular longevity, and maximize autophagy.
- Turmeric Extract contains bioactive curcuminoids that promote autophagy, modulate inflammatory response, and support healthy cellular health.
- Pterostilbene helps in the activation of SIRT1 pathways and is more bioavailable than resveratrol. Supports healthy cognitive functioning, and cellular cleanup.
- Magnolia Bark Extract helps in supporting stress relief, regulates autophagy pathways, and boosts cellular health to reduce inflammation and enhance longevity.
Get Started with Building Your Custom Inflammaging Formulation
Learn more about our in-house formulations that address Inflammaging in partnership with Functional Genomic Nutrition and Bob Miller by scheduling your free consultation session with Personalized Nutrients.
