At Personalized Nutrients, we’re excited to share this breakthrough in natural weight management. Gateway’s latest clinical research delivers compelling insights into Dyglomera (Dyglofit from Dichrostachys Glomerata) and Cissus Quadrangularis. These ingredients don’t just support weight loss. They regulate appetite, promote metabolic balance, and drive meaningful outcomes by enhancing the body’s own GLP-1 activity.
The Science: New Clinical Data on Natural GLP-1 Boost
In a robust randomized, double-blind, placebo-controlled study of 248 overweight and obese adults lasting 16 weeks, both Dyglomera and Cissus Quadrangularis proved their power. They work by modulating dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for rapidly degrading GLP-1.
Key Outcomes from the 16-Week Human Trial
Clinical results on Dyglomera and Cissus Quadrangularis indicate tremendous potential for overall health improvement.
| INGREDIENT | GLP-1 Increase | DPP-4 Activity Reduction | Average Body Weight Loss | Body Fat Reduction |
| Dyglomera (Dyglofit) | 295% | -15.3% | 5.2% | 10.3% |
| Cissus Quadrangularis (Cissus) | 321% | -17.8% | 5.8% | 10.9% |
Both extracts also produced significant improvements in key metabolic markers, including reductions in fasting glucose, triglycerides, and LDL cholesterol, alongside increases in beneficial HDL cholesterol.
Unlike synthetic GLP-1 ingredients that introduce external hormones into the body, Dyglomera and Cissus Quadrangularis work with your physiology. They support the body’s own hormone production and regulation, creating a coordinated multi-pathway response that extends beyond GLP-1 alone. This distinction matters for:
- Physiological alignment: Both the extracts enhance what your body already does naturally, rather than replacing or overriding normal function.
- Comprehensive metabolic support: The benefits extend across hormonal and metabolic systems, addressing multiple aspects of metabolic health simultaneously.
- Sustainable intervention: By working with the body’s existing pathways, the two botanicals offer better long-term viability for daily use.
By Reducing DPP-4 Activity, GLP-1 Remains Active Longer in the Body
Dyglomera and Cissus Quadrangularis enable GLP-1 to remain active longer without overriding the body’s inherent regulatory systems. They provide a coordinated, multi-pathway response across hormonal and metabolic systems, not just GLP-1 alone. This supports:
- Appetite regulation and prolonged satiety after meals.
- Healthy post-meal glucose handling.
- Normal metabolic signaling for daily, long-term use.
Ready to Integrate Dyglomera and Cissus Quadrangularis into Your Practice?
For practitioners seeking evidence-based natural approaches to weight management for their patients, Dyglomera and Cissus Quadrangularis represent scientifically validated options backed by rigorous clinical research.
Full Study Reference – “Clinically Validated Weight Management Support.”
(A must-read clinical tool for integrative medicine practitioners targeting natural GLP-1 strategies.)
These two botanical extracts open new possibilities for tailored, physiologically aligned wellness strategies when combined with Personalized Nutrients’ expertise in building high-impact custom protocols for individual patient needs.
Start building your custom formula today.
