Heme is a critical substance in the body as it is a cofactor for the Cytochromes P450s in phase 1 Detox. It is also needed for nitric oxide for circulation and for the SUOX enzyme to convert sulfites into sulfates for the critical Phase II Sulfation process.
Heme is made from glycine and Succynl-CoA from the Krebs Cycle, and if anything would interfere with this such as pesticides or mitochondrial disfunction, heme may be less than optimal. Additionally genetic mutations in the eight enzymes that make heme production could create less heme. Plus the heavy metal lead may impair the production with heme by blocking the enzymes ALAD and FECH. Finally if anything disrupts the heme cycle Porphyrins may block the GABA receptor sites creating anxiety.
- Constant hunger for hunger for carbohydrates
- Craving alcohol
Heme is also needed for the powerhouse enzyme Heme oxygenase which turns oxygenated Fe2 into Ferritin and creates vary small amounts of carbon monoxide which is surprisingly anti-inflammatory. Bilirubin is also created, and when made in small amounts it’s as powerful as Glutathione as an antioxidant.
It may lower TNF-a, NF-Kb, IL-6 and NOX… that can be up regulated by Mycotoxins, Lipopolysaccharides, Virus, or Heavy metals. As a result this can create Mast Cells and excess Histamine.
Introducing Krebs/Heme Assist –
Key Ingredients in Krebs/Heme that Stimulate Succinyl-CoA and Cofactors needed by the Heme Enzymes include:
- Alpha Ketoglutaric
Serving Size – 3 Capsules Per Day