Regulating Histamine in the body and recycling Glutathione is highly essential because not only it helps to reduce oxidative stress in the body, but also helps in keeping mitochondrial dysfunction away. So, your patients need to have some sort of Custom supplement formulation in their supplementation regime to better tackle this aspect.
What leads to Mitochondrial Dysfunction and Oxidative Stress?
Although Arachidonic acid plays many important roles in the body when it is pulled out of the membranes by the PLA2 enzyme, it may create excess histamine, prostaglandins through COX2, Vasoconstriction, and potential Platelet activation through Thromboxane as well as acute and chronic Inflammation caused by 5-LOX creating Leukotrienes and through 12-LOX, potentially creating mitochondrial dysfunction and oxidative stress.
This may lead to Adrenal weakness as the Adrenals struggle to make the cortical steroids as it’s trying to calm PLA2.
Potential triggers for PLA2 activation through TNF may be through mycotoxins, viruses, lipopolysaccharides, Borrelia, mercury, and pesticides that stimulate TNF-a and NF-Kb.
Introducing PLAX – Comprehensive Custom Supplement Formulation
Compounded Nutrients presents one of the best personalized Nutritional Supplements that help in regulating histamine levels in your patients and also help in recycling glutathione. Through this, patients can avoid mitochondrial dysfunction and oxidative stress.

Key Ingredients in PLAX and their functions:
Calm TNF-a and COX2
- Black Cumin Seed Oil – 100mg
- Panex Ginseng – 50 mg
Calm PLA2
- Grapeseed Extract – 100 mg
- Resveratrol – 50 mg
- DHA – 100 mg
- CDP Choline – 225 mg
- Ginkgo – 100 mg
Support the Adrenals
- Pantethene – 100 mg
Reduce Histamine
- DAO –
Reduce the Free Radical Super Oxide
- Superoxide Dismutase – 5 mg
Reduce Peroxy Nitrite
- Pine Bark – 100 mg
Support Removal of Histamine and Recycle Glutathione
- Riboflavin 0 45 mg
Serving Size – 2 Capsules Per Day